I suggest that the mirror less bodies are the go-to choice. They have the advantage of having a shallower depth from lens mount to sensor, providing room for adapters. For example, all Canon R series bodies are capable of using native, plus, with adapters, DSLR and vintage lenses.
I have an R5 with an RP backup, both full frame. For glass, I have several RF native lenses in L and non L qualities, several EF lenses I use with an EF/RF adapter, a couple of Nikon DX automatic lenses with an F/RF adapter that provides manual control of aperture, and a few M42 mount vintage and SuperTakumar lenses I install with an M42/RF adapter. This flexibility and the ability to go back to some wonderful old 35mm film lenses means I can revisit lenses that cannot be used with DSLR bodies, as their are relatively few adapters, or no room to make them work. I have never found the adapters added to the lens length an issue, as they are only about 3/4" deep, and weigh next to nothing.
The ability to use the EF lenses at great prices today (new and used) plus application of 3rd party glass readily available for EF, gets around Canon's blockade of 3rd party supply of full frame R lenses, and some of their insane RF L glass pricing. In a recent purchase, I picked up a lightly used Tamron EF mount SP45mm lens that is near L glass outstanding, and includes stabilization and weather sealing - for less than the lower end unsealed, good-enough grade RF glass, so it is a win win.
I prefer full frame over ASPC or M4/3 as I don't like the whole crop factor messing with the optics, like having to have a 35mm lens to get 56mm field of view and the imposition of that crop on every lenses characteristic center to corner/edge rendering. With full frame, the lens is what it says on it, and the vintage 35mm film glass works as it should including the desired optical effects that make them so special.
I also believe that over time, buying lenses for crop sensor bodies just creates an inventory of lenses that jam you up in having to crop a full frame sensor later, which really cuts resolution down - ex: a 45mp full frame sensor in 1.6 crop mode to use crop sensor lenses, becomes a 28mp sensor, and 26mp sensor is cut down to 16mp. I can always use a crop lens today on a full frame sensor, but in the future, any crop lenses (like the Nikon DX lenses I have) will be relegated to cropped reduced resolution mode that reduces their utility and value (I keep them only because they are good lenses, of too little value to sell or trade in). Since the future is likely to continue to drive toward full frame sensors with higher mp count (from 45 to 100+, global, etc), I see no reason to buy glass (which can last decades if properly cared for) that reduces the value of future tech updates in the body.